Thrombolytic Therapy in the Acute Management of Frostbite Injuries

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Use of Intra-arterial Thrombolytic Therapy for Acute Treatment of Frostbite in 62 Patients with Review of Thrombolytic Therapy in Frostbite

Amputations are common after severe frostbite injuries, often mediated by postinjury arterial thrombosis. Since 1994, the authors have performed angiography to identify perfusion deficits in severely frostbitten digits and treated these lesions with intraarterial infusion of thrombolytic agents, usually combined with papaverine to reduce vasospasm. A retrospective review was performed of patien...

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Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy.

HYPOTHESIS Thrombolytic therapy will decrease the incidence of amputation when administered within 24 hours of exposure. DESIGN Single institution retrospective review of clinical outcomes and resource use. SETTING Burn unit of a tertiary academic referral center. PATIENTS From 2001 to 2006, patients with severe frostbite admitted within 48 hours of injury underwent digital angiography an...

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Acute occlusion of the superior mesenteric artery (SMA) causes extensive bowel necrosis, resulting in a poor prognosis with an extremely high mortality rate. An 82-year-old woman was admitted to our hospital with the complaint of abdominal pain. She was diagnosed as having acute SMA occlusion by enhanced CT. Five hours from onset, the first thrombolytic therapy with urokinase was performed, but...

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Thrombolytic therapy of acute stroke.

Case 1. A 65-year-old right-handed man with no history of heart disease presented to the emergency department with right-sided weakness and an inability to speak. His wife last saw him well 1 hour before his arrival. His ECG showed atrial fibrillation with a ventricular response of 100 bpm; his blood pressure was 175/ 88 mm Hg. He was alert, but he did not produce or comprehend speech. He did n...

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ژورنال

عنوان ژورنال: Air Medical Journal

سال: 2011

ISSN: 1067-991X

DOI: 10.1016/j.amj.2010.08.006